PGT-SR- Preimplantation Genetic Testing for Chromosomal Structural Rearrangement
Prevent the transfer of embryos with abnormal chromosome structure.
You are indicated for PGT-SR if you or your partner is a carrier of
- Reciprocal Translocation
- Robertsonian Translocation
- Inversion
- Insertion
We introduced third-generation long-read sequencing in distinguishing normal from balanced carrier embryos in 2018, allowing the couple to selective transfer of euploid non-carrier embryo [1]. This helps to prevent the vertical transmission of chromosomal structural rearrangement to next generation.
UniPGT-plus also identifies euploid non-carrier embryo when reference is available.
- Chow JFC, Cheng HHY, Lau EYL, Yeung WSB, Ng EHY: Distinguishing between carrier and noncarrier embryos with the use of long-read sequencing in preimplantation genetic testing for reciprocal translocations. Genomics 2020, 112(1):494-500.