{"id":537,"date":"2020-10-06T15:06:45","date_gmt":"2020-10-06T07:06:45","guid":{"rendered":"https:\/\/nhkuivf.hku.hk\/?page_id=537"},"modified":"2025-07-17T16:49:06","modified_gmt":"2025-07-17T08:49:06","slug":"chromosomal-abnormality","status":"publish","type":"page","link":"https:\/\/hkuivf.hku.hk\/en\/services\/preimplantation-genetic-testing\/chromosomal-abnormality\/","title":{"rendered":"PGT-SR- Preimplantation Genetic Testing for Chromosomal Structural Rearrangement"},"content":{"rendered":"<p>Prevent the transfer of embryos with abnormal chromosome structure.<\/p>\n<p>You are indicated for PGT-SR if you or your partner is a carrier of<\/p>\n<ul>\n<li>Reciprocal Translocation<\/li>\n<li>Robertsonian Translocation<\/li>\n<li>Inversion<\/li>\n<li>Insertion<\/li>\n<\/ul>\n<p>We introduced third-generation long-read sequencing in distinguishing normal from balanced carrier embryos in 2018, allowing the couple to selective transfer of euploid non-carrier embryo [1]. This helps to prevent the vertical transmission of chromosomal structural rearrangement to next generation.<\/p>\n<p><strong>UniPGT-plus<\/strong> also identifies euploid non-carrier embryo when reference is available.<\/p>\n<ol>\n<li>Chow JFC, Cheng HHY, Lau EYL, Yeung WSB, Ng EHY: <strong>Distinguishing between carrier and noncarrier embryos with the use of long-read sequencing in preimplantation genetic testing for reciprocal translocations<\/strong>. <em>Genomics <\/em>2020, <strong>112<\/strong>(1):494-500.<\/li>\n<\/ol>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Prevent the transfer of embryos with abnormal chromosome structure. You are indicated for PGT-SR if you or your partner is a carrier of Reciprocal Translocation<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":206,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-537","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/pages\/537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/comments?post=537"}],"version-history":[{"count":5,"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/pages\/537\/revisions"}],"predecessor-version":[{"id":1273,"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/pages\/537\/revisions\/1273"}],"up":[{"embeddable":true,"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/pages\/206"}],"wp:attachment":[{"href":"https:\/\/hkuivf.hku.hk\/en\/wp-json\/wp\/v2\/media?parent=537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}